PCORI Help Center

Which interventions are eligible? 

Studies may focus on pre-and/or postnatal care and should compare multicomponent, multilevel interventions. An intervention is considered multilevel if it addresses the individual patient, as well as at least two levels of contextual influence, such as organizations and providers or communities, thereby targeting at least three different sources of influence. Interventions should include at least one component from each of the following categories: 

  • Strategies to address social determinants of health. 
  • Health systems strategies to address disparities in maternal health outcomes. 

Applicants should propose interventions that have evidence of efficacy or are in use in relevant settings and populations. Multicomponent interventions that do not have evidence and are not in widespread use may be proposed; however, the individual components must be evidence-based or in widespread use, measurable, and reproducible. Applicants may use interventions or components of interventions that have documented efficacy in other populations or for other conditions with some adaptation if necessary—if based on a sufficiently strong rationale for why the intervention would be expected to be efficacious in the proposed setting(s) and/or population(s). Justification of prior efficacy or use could include, but is not limited to, findings from pilot studies, clinical trials, literature reviews, clinical practice guidelines, and standardized usual care protocols. If usual care is included as a comparator, it must be well-justified, well-defined, and sufficiently measurable. 

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