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Which types of research designs are eligible for this funding announcement? 

Large randomized controlled trials (RCTs) are preferred; robust observational studies will also be considered if an RCT is not possible, and the proposed approach appropriately controls for confounding. Thoughtful use of hybrid designs also is encouraged and could speed the translation of research findings into routine practice, identify more effective implementation strategies, and provide more useful information for stakeholders. For this PFA, one of the primary aims must be focused on a CER question, so hybrid type 1 and hybrid type 2 designs may be appropriate. Hybrid type 3 designs, for which the primary aim is implementation research, will not be considered responsive. 

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