Multimodal approaches, including pharmacologic, diet, exercise, case management, and/or other interventions are eligible. PCORI is interested in comparing combinations and/or sequences of interventions. The intervention should either be in common use or have evidence of efficacy. Regardless, proposed combinations or sequences of interventions should address actual clinical choices faced by patients, caregivers, and clinicians in specific practice settings. In addition, alternative models of care delivery and coordination can be included.
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