PCORI Help Center

Can One Comparative-Treatment Option Be A New Option For Patients? For Example, Enhanced Care Based On The Literature But Not Currently In Routine Practice?

Generally, a new option is less desirable than an option that is commonly available; however, if the new option has previously been demonstrated to be efficacious or effective in one or more controlled trials and is likely to become commonly available, then it is legitimate to compare its real-world effectiveness to that of other available options. 

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