Yes--Interventions to reduce persistent disparities are often multifactorial, complex, and context specific. Often, evidence-based interventions have been shown to be effective in the general population but lack evidence for effectiveness in those populations at risk for disparities. The Addressing Disparities priority area is thus interested in funding studies that tailor and test these types of interventions.
Applicants may use interventions that have documented efficacy or effectiveness in similar situations with some adaptation if necessary—if the efficacy is well documented (e.g., with prior research or with a systematic review) and based on a sufficiently strong rationale for why the intervention would be expected to be efficacious in the proposed new setting(s) and/or population(s). If an intervention is to be adapted, PCORI expects most of the proposed time and budget to aim at establishing comparative effectiveness rather than adapting and validating the interventions.