Will the multiple PI structure be the same for this mechanism as it has been for PCORI’s prior science PFAs? Can a stakeholder (still) serve as a co-PI?

The PLACER PFA recommends a dual-PI arrangement for this PFA where one PI is based at the data coordinating center; a strong justification is required for any alternative to this arrangement. Given the size, complexity, and anticipated risks of the research sought by PCORI under PLACER, it is unlikely that a stakeholder can meet the necessary requirements of a dual-PI. Applicants should consider whether important stakeholder leadership and input can be achieved through other organizational and management arrangements.