PCORI assigns applications to Reviewers based on availability, experience, and corresponding fit with the applications in the panel. Individuals who have been invited to serve as a PCORI Reviewer will be asked to indicate their availability to serve before a new cycle begins. In this correspondence, a Reviewer will indicate whether he or she is able to complete all assignments and attend the in-person Merit Review meeting. After participant availability is determined, PCORI assesses its need for specific Reviewer types based on the quantity and topic areas of applications received for that cycle. A subset of available Reviewers are then invited to self-rate their expertise and indicate any conflicts of interest (COIs) on the applications in each panel for a particular PFA.