How final should the research plan be at the outset of the award? Should awardees plan for modifications in the event that patient partners have input that prompts changes?

All proposals should be drafted to give merit reviewers the best picture of what is being proposed. Therefore, plan should be submitted with as much detail as possible.

For Broad PFAs, patient partners should ideally be involved early in the process, thereby minimizing the need for modifications. 

For Targeted PFAs and Pragmatic Clinical Studies (PCS), it is expected that, once awarded, the Study Advisory Committee or other appropriate engagement body will assist the research team with refining the study questions, outcomes, and protocols.