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Must both strategies compared in the study be opioid dose reduction strategies or can one be an opioid risk reduction strategy?

It is up to the applicants to decide what comparators that are deem important for the proposed study. The applicants should justify the rationale for selecting the comparators and address the question posed in the PFA—keeping in mind that PCORI’s goal is to reduce harms associated with chronic opioid therapy while controlling pain. The applicants should also select comparators that are meaningful. Think about the choices that providers/decision makers are facing and -frame your study around these choices. The interventions being compared should provide better evidence to inform those choices.

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