Yes. However, PIs are invited to submit an application based on the information provided in the LOI. Any changes to the following require PCORI's written approval prior to submission:
- Principal Investigator
- Study design
- Research question(s)
- Specific aims
To request approval for any of the above changes, the Principal Investigator and Administrative Official listed on the LOI should email email@example.com and clearly specify the requested change, rationale, and impact to the project. Due to the volume of requests PCORI received, applicants should submit the request early during the application process.