Can the information proposed in an application differ from the research initially described in the Letter of Intent (LOI)? – PCORI Help Center

Yes. However, PIs are invited to submit an application based on the information provided in the LOI. Any changes to the following require PCORI's written approval prior to submission:

Principal Investigator
Institution
Study design
Research question(s)
Specific aims
Comparators

To request approval for any of the above changes, the Principal Investigator and Administrative Official listed on the LOI should email pfa@pcori.org and clearly specify the requested change, rationale, and impact to the project. Due to the volume of requests PCORI received, applicants should submit the request early during the application process.