Will a proposal that includes a cost-effectiveness analysis as a secondary aim be deemed nonresponsive?

Yes. LOIs that propose to conduct cost-effectiveness analysis in any capacity, if invited to submit a full application, will be asked to remove this aim in their full application.  If this aim is not removed, those applications that conduct cost-effectiveness analysis in any capacity may be deemed nonresponsive, and may not proceed to Merit Review.

 Secondary outcomes may include changes in healthcare utilization, but the project may not incorporate such outcomes into cost-effectiveness analysis.