PIs should not make any major changes–such as research question(s), study design, specific aims, comparators, institution or Principal Investigator–to their application. LOIs go through a competitive process and PIs are invited to apply based on the information provided. If you need to change any of this information or have any questions, email firstname.lastname@example.org.
Can the research proposed in an application differ from the research initially described in the LOI?
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