PCORI Help Center

Can the research proposed in an application differ from the research initially described in the LOI?

PIs should not make any major changes–such as research question(s), study design, specific aims, comparators, institution or Principal Investigator–to their application. LOIs go through a competitive process and PIs are invited to apply based on the information provided. If you need to change any of this information or have any questions, email pfa@pcori.org.

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