What is PCORI's definition of unsafe prescribing?

It is up to the applicant to define unsafe prescribing in the context of their particular proposal as well as describe how it will be measured. This will depend on the population being targeted (e.g., acute versus chronic pain), the setting in which prescribing takes place (e.g., primary care physician versus emergency department), whether a specific condition is being targeted (e.g., back pain versus fibromyalgia), and other contextual factors.