May our proposed study address both of the priority research questions?

It is acceptable to address both research questions in one proposal, as long as you feel the proposed methods and sample size are adequate to address both. If you choose to address both research questions, you should justify your decision to do so. The budget limit of $5 million total cost would still apply to your entire application, unless you receive prior approval to exceed this amount. Approvals for additional funds are anticipated to be rare.