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How is “sequenced intervention” being defined?

PCORI does not have specific requirements for sequenced interventions. We are relying on study investigators to propose sequences of interventions based upon the available evidence and documented patterns of actual use. In general, a sequenced intervention employs two or more treatments that are implemented in a planned temporal order. Treatments may be discrete or overlap in time. In addition, proposed sequences of interventions must address actual clinical choices faced by patients, caregivers, and clinicians in specific practice settings. As further noted in the PFA, “For sequenced approaches, a rationale based on the available empirical evidence and documented common use should be included (e.g., simplest to most complex, patient-preferred, patient profile-determined, or randomized treatment sequence).”

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