Are Letters of Intent (LOI) required?
Yes. All applicants must submit an LOI before they submit an application. PCORI will only invite applicants whose LOIs are deemed most responsive to this PFA to submit a full application.
What information is required for the LOI?
The LOI for the proposed project should contain all information in the LOI template, including:
- Title of proposed implementation project
- The original PCORI research award number, PFA under which the original research award was funded, project title, and the name of the original PI.
- Anticipated date results will be ready
- Clear identification and a description of the research findings to be implemented, including their clinical meaningfulness and statistical significance, as well as their generalizability
- Objective and specific aims of the proposed project
For Standard Implementation Projects:
- Description of how the implementation project is an appropriate next step toward integrating and using evidence from the PCORI-funded study in real-world settings, including what the project will accomplish
- A clear description of the implementation strategy and approach, including any translation or adaptations needed to promote accessibility, use, and uptake of the research findings
- Clear identification and a description of the setting(s) in which implementation will occur and of the participants who will be involved
- A description of the evaluation plan, including an appropriate balance of measurable outcomes that document both the successful performance of implementation activities in getting the intervention into practice and the impact of these activities on outcomes such as behavior change, healthcare utilization, and health
- Stakeholder engagement in the planning and execution of this implementation effort
- Indication of whether the proposed project is a resubmission
For Phased Implementation Projects
- In addition to the information included in the Standard Implement Project (above), applicants should provide:
- Justification for why the proposed project warrants the larger phased initiative approach rather than the standard implementation approach.
- Rationale for selection of Phase 1 and Phase 2 sites, including why the proposed Phase 1 sites will best inform implementation of Phase 2 sites
- Description of the readiness of the proposed sites, including significant stakeholder /partner buy-in and commitment to use the intervention during and beyond the PCORI-funded project
- Description of the evaluation plan, including measures that will document the feasibility and impact of the project during Phase 1 that will determine whether continuation to Phase 2 is warranted, as well as measures of costs of implementation during Phase 2 to inform further scaleup.
For Dissemination Projects
- Description of the overall dissemination strategy and approach, including why the proposed dissemination activity – rather than implementation – is an essential and appropriate next step for progress toward near-term or eventual uptake of evidence
- A clear description of the target audience, including previous partnerships with the target audience, as well as the number of individuals who will be reached
- Description of the dissemination setting(s) and channels/mechanisms that will be used to reach the target audience
- A description of the evaluation plan, including measurable indicators of success
- Stakeholder engagement in the planning and execution of this dissemination effort
- Indication of whether the proposed project is a resubmission
How much can the protocol proposed in my application differ from that initially described in my LOI?
Applicants should not make major changes to their application, including to the implementation approach, specific aims, institution, or PI without prior approval from the D&I program. LOIs are invited to apply based on the information provided. If you need to change any of this information or have any questions, email firstname.lastname@example.org.
Can I list a different PI in the final application than was listed in the LOI?
Changes in the PI or institution between the LOI and application phase require approval from PCORI’s program staff before submitting the full application. Submit the request to email@example.com and include a rationale for the change, Letter of Support from the intended PI, and a cover letter or biosketch for the replacement PI.
If I do not submit an LOI, can I still submit an application? (I missed the deadline to submit an LOI. Can I still submit an application?)
No, only applicants who submit an LOI can submit an application.
Can the PI submit the LOI via his or her account, or does the LOI need to be submitted by the institutional Administrative Official?
The PI should submit the LOI for the project, as the PI will be serving as our main point of contact. An Administrative Official is required to submit the full application.
Can multiple people access the LOI?
Yes. The PI may assign a “PI Designee” to access and edit the LOI. Only one person may work on the application in PCORI Online at a time.
What budget information is required for the LOI? How detailed does it need to be?
Only a budget estimate is required to complete the LOI. PCORI will advise applicants who are invited to submit a full application as to the acceptability of the budget proposed in their LOI.
What if I need more time or funding than is allowed for this PFA?
- For Standard Implementation Projects: Up to $1.5 million in total direct costs. Applicants will indicate the funds requested from PCORI when submitting their Letter of Intent (LOI). PCORI will advise applicants that are invited to submit a full application as to the acceptability of the budget proposed in their LOI. In general, applications requesting budgets larger than $500,000 in total are expected to demonstrably and significantly increase the reach of the evidence.
- For Phased Implementation Projects: Up to $1.5 million in total direct costs for Phase 1 and up to $3 million in total direct costs for Phase 2. Total direct costs for the full proposal should not exceed $4.5 million. Applicants will indicate the funds requested from PCORI when submitting their Letter of Intent (LOI). PCORI will advise applicants that are invited to submit a full application as to the applicability of the budget proposed in their LOI. Applicants proposing Phased Implementation Projects may be asked to reduce their budget and submit a full application for a Standard Implementation Project.
- For Dissemination Projects: Up to $300,000 in total costs, with clear and adequate justification.
How soon after I submit my LOI can I begin my application?
Only applicants whose LOIs are deemed most responsive to this PFA will be invited to submit a full application. Invited applicants may begin the application process as soon as they receive their LOI feedback, about a month after the LOI due date.
How should I format my LOI using the template PCORI provides?
All LOIs are required to use Calibri font size 11 and single spacing. Replace the italicized gray and any instructional text with your response. You must retain the bold headings and question numbers and write your response directly after the bold heading. Applicants are also required to use half-inch margins (the header may fall within the top margin, but the body text should not begin closer than a half-inch from the edge of the page). You do not have to provide spaces between questions. See the Submission Instructions for more information.