PCORI Help Center


Are Letters of Intent (LOI) required?
Yes. All applicants must submit an LOI before they submit an application. Beginning January 2017, the D&I LOI review will be competitive: only applicants whose LOIs are deemed most responsive to this PFA will be invited to submit a full application.

What information is required for the LOI?
The LOI for the proposed project should contain the following information:

  • Title of proposed project
  • Original PCORI research award number, project title, and name of PI
  • Indication of whether the proposed project is a resubmission 
  • Indication of whether the proposed project is a collaborative project
  • Clear identification and description of the research results to be disseminated, including a clear description of the strength of these findings that justifies interest in disseminating them
  • Identification of the evidence gap the research results fill, and the significance of the finding in the context of existing literature
  • Objective and specific aims of the proposed D&I project
  • Clear description of the approach for disseminating the research finding
  • Clear identification and description of the setting in which dissemination will take place, the immediate target of the dissemination activity, and the ultimate link to changes in healthcare delivery and health outcomes
  • Description of the evaluation plan, including measurable process and short-, intermediate-, and longer-term outcomes you will use to capture timely information on the effectiveness of the proposed D&I activities, including impact on the end-user
  • Patient and other stakeholder engagement in the planning and implementation of this D&I effort

How much can the protocol proposed in my application differ from that initially described in my LOI?
Applicants should not make major changes–such as dissemination approach, specific aims, institution or PI – to their application without prior approval from the D&I Program. LOIs are invited to apply based on the information provided. If you need to change any of this information or have any questions, email pfa@pcori.org.

Can I list a different PI in the final application than was listed in the LOI?
No; if the PI changes between the LOI phase and the application phase, applicants must speak with a Program Officer before the deadline to obtain approval. Failure to obtain written approval prior to the deadline may result in the application being rejected.

If I do not submit an LOI, can I still submit an application? (I missed the deadline to submit an LOI. Can I still submit an application?)
No, only applicants who submit an LOI can submit an application.

Can the PI submit the LOI via his or her account, or does the LOI need to be submitted by the institutional Administrative Official?
The PI should submit the LOI for the project, as the PI will be serving as our main point of contact. An Administrative Official is required to submit the full application.

Can multiple people access the LOI?
Yes. The PI may assign a “PI Designee” to access and edit the LOI. Only one person may work on the application in PCORI Online at a time.

What budget information is required for the LOI? How detailed does it need to be?
Only a budget estimate is required to complete the LOI. PCORI will advise applicants who are invited to submit a full application as to the acceptability of the budget proposed in their LOI.

What if I need more time or funding than is allowed for this PFA?

PCORI encourages projects that will be completed within a 2-year project period, at the level of $350,000 in direct costs, but will accept applications requesting up to $1,000,000 and requests for a longer project period up to 3 years with clear and adequate justification. Applicants will indicate the funds requested and intended project period when submitting their LOI. PCORI will advise applicants who are invited to submit a full application as to the acceptability of the budget and project period proposed in their LOI.

In general, adequate justification for requesting larger budgets and/or additional time will include a demonstrable ability to significantly increase the reach (i.e., substantially more targeted end users), generalizability (applicability of intervention across different groups, systems, settings), and uptake (use and adoption among more systems, settings or sites) of the evidence proposed for dissemination and implementation.

PCORI will not consider projects requesting funds in excess of $1,000,000 direct costs and/or time greater than three years for this PFA.

How soon after I submit my LOI can I begin my application?
Only applicants whose LOIs are deemed most responsive to this PFA will be invited to submit a full application. Invited applicants may begin the application process as soon as they receive their LOI feedback, about a month after the LOI due date. However, the PCORI draft final research report must be submitted prior to the application deadline.

How should I format my LOI using the template PCORI provides?
All LOIs are required to use Calibri font size 11 and single spacing. Replace the italicized gray and any instructional text with your response. You must retain the bold headings and question numbers and write your response directly after the bold heading. Applicants are also required to use half-inch margins (the header may fall within the top margin, but the body text should not begin closer than a half-inch from the edge of the page). You do not have to provide spaces between questions. Please view the LOI sample template.

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