Patients with an advanced illness are broadly defined as those who experience a high symptom burden with a life-limiting disease diagnosis. Conditions may include (but are not limited to) advanced heart failure, cancer, chronic obstructive pulmonary disease, or neurodegenerative diseases. For the inclusion of cancer, applicants should consider advanced stages and make the case for the appropriateness of their participants within the parameters of this PFA. Proposals that focus on populations living with a chronic disorder that is NOT life-limiting, such as hypertension, will be considered nonresponsive to this PFA.
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