For this funding announcement, patients with an advanced illness are broadly defined as those who experience a high symptom burden with a life-limiting disease diagnosis. Conditions may include, but are not limited to, advanced heart failure, cancer, chronic obstructive pulmonary disease, end-stage liver and kidney disease, or neurodegenerative diseases, as well as combinations of the above. Many individuals with an advanced illness also live with chronic illness. Individuals living with only a chronic disorder such as hypertension are not the focus of this funding announcement. For the inclusion of cancer, investigators should consider advanced stages and make the case for the appropriateness of their participants within the parameters of this PFA.
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