Is the Migraine funding opportunity only interested in CGRP comparisons?

No, this funding opportunity is soliciting studies that compare emerging pharmacological options to standard prophylactic therapy or to each other. PCORI is also interested in studies that examine the comparative effectiveness of evidence-based nonpharmacological options for migraine prevention. As appropriate, studies may include nonpharmacological interventions as stand-alone therapy or as an adjunct to pharmacological options. Applicants should provide an evidence-based argument for the relevance of the treatment options being compared, citing evidence gaps to be addressed that are supported by systematic reviews.