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Are comparators aimed at preventing associated symptoms of migraines (such as recurrent gastrointestinal disturbance, benign paroxysmal vertigo, and benign paroxysmal torticollis) considered appropriate and responsive to this funding opportunity?

No, the focus of this funding opportunity is migraine prevention. There are some conditions that are associated with migraine but the focus is not on preventing these additional conditions. However, this proposed work may be considered responsive to PCORI's Broad Pragmatic Studies Funding Announcement as the broad funding mechanism seeks investigator-initiated applications for patient-centered comparative clinical effectiveness research (CER) projects aligned with our priority areas for research.

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