Foreign Organizations and Nondomestic Components of U.S. Organizations must provide a thorough and thoughtful justification for the research's ability to benefit the US healthcare system and that the engagement plans include US patients and stakeholders and are relevant to US healthcare system (https://www.pcori.org/funding-opportunities/what-who-we-fund).
However, PCORI’s programmatic research priority will be to identify the utility of interventional impacts on U.S. older adult populations, and particularly on Medicare and Medicaid covered and eligible populations. Therefore, PCORI expects all sites of research in this PFA to be based in the U.S. Exceptions could be made for foreign institutions’ participation, contingent upon a clear benefit or applicability to the U.S. system that is demonstrated in the application.